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, 145 (4), 257-9

Revisiting the Role of Raphe and Serotonin in Neuropsychiatric Disorders


Revisiting the Role of Raphe and Serotonin in Neuropsychiatric Disorders

Albert Adell. J Gen Physiol.


Figure 1.
Figure 1.
Schematic drawing of a 5-HT neuron showing exocytotic release from vesicles (red arrow) and the nonexocytotic release described by Mlinar et al. (2015) (blue arrow). Reuptake of 5-HT through SERT is depicted with a green arrow. SSRIs block SERT, thus inhibiting reuptake of 5-HT. Monoamine oxidase (MAO) enzyme is located in the external mitochondrial wall.

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    1. Adell A., and Artigas F. 1991. Differential effects of clomipramine given locally or systemically on extracellular 5-hydroxytryptamine in raphe nuclei and frontal cortex. Naunyn Schmiedebergs Arch. Pharmacol. 343:237–244. 10.1007/BF00251121 - DOI - PubMed
    1. Adell A., Sarna G.S., Hutson P.H., and Curzon G. 1989. An in vivo dialysis and behavioural study of the release of 5-HT by p-chloroamphetamine in reserpine-treated rats. Br. J. Pharmacol. 97:206–212. 10.1111/j.1476-5381.1989.tb11943.x - DOI - PMC - PubMed
    1. Adell A., Celada P., Abellán M.T., and Artigas F. 2002. Origin and functional role of the extracellular serotonin in the midbrain raphe nuclei. Brain Res. Brain Res. Rev. 39:154–180. 10.1016/S0165-0173(02)00182-0 - DOI - PubMed
    1. Artigas F., Romero L., de Montigny C., and Blier P. 1996. Acceleration of the effect of selected antidepressant drugs in major depression by 5-HT1A antagonists. Trends Neurosci. 19:378–383. 10.1016/S0166-2236(96)10037-0 - DOI - PubMed
    1. Asberg M., Thorén P., Träskman L., Bertilsson L., and Ringberger V. 1976. “Serotonin depression”—a biochemical subgroup within the affective disorders? Science. 191:478–480. 10.1126/science.1246632 - DOI - PubMed