Changes in anti-endotoxin-IgG antibody and endotoxaemia in three cases of gram-negative septic shock

Circ Shock. 1989 Oct;29(2):93-106.


Circulating endotoxin levels and IgG antibodies to a range of Gram-negative bacterial lipopolysaccharides (LPS) (endotoxins) of different sizes and structures were measured daily in three cases of septic shock. There was an inverse relationship between endotoxin levels and cross-reactive antibodies to the core glycolipid (CGL) region of lipopolysaccharide. This suggests that antibody to LPS-CGL was initially consumed by a superabundance of endotoxin, and that a resurgence of intrinsic anti-LPS-CGL antibody levels may be associated with a reduction of circulating endotoxin. The implications of these findings for passive antibody therapy of septic shock are discussed.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-Bacterial Agents / therapeutic use
  • Antibodies, Bacterial / analysis*
  • Endotoxins / blood
  • Endotoxins / immunology*
  • Female
  • Humans
  • Immunoglobulin G / analysis
  • Immunoglobulin G / immunology*
  • Immunoglobulin G / physiology
  • Lipopolysaccharides / blood
  • Lipopolysaccharides / immunology*
  • Male
  • Pneumococcal Infections / blood
  • Pneumococcal Infections / immunology
  • Pneumococcal Infections / therapy
  • Shock, Septic / blood
  • Shock, Septic / immunology*
  • Shock, Septic / therapy
  • Time Factors


  • Anti-Bacterial Agents
  • Antibodies, Bacterial
  • Endotoxins
  • Immunoglobulin G
  • Lipopolysaccharides
  • core endotoxin