Muscle-building supplement use and increased risk of testicular germ cell cancer in men from Connecticut and Massachusetts

Br J Cancer. 2015 Mar 31;112(7):1247-50. doi: 10.1038/bjc.2015.26.


Background: No analytic epidemiological study has examined the relationship between use of muscle-building supplements (MBSs) and testicular germ cell cancer (TGCC) risk.

Methods: We conducted a population-based case-control study including 356 TGCC cases and 513 controls from Connecticut and Massachusetts.

Results: The odds ratio (OR) for ever use of MBSs in relation to risk of TGCC was significantly elevated (OR=1.65, 95% confidence interval (CI): 1.11-2.46). The associations were significantly stronger among early users, men with more types of MBSs used, and longer periods of use.

Conclusions: MBS use is a potentially modifiable risk factor that may be associated with TGCC.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Case-Control Studies
  • Connecticut / epidemiology
  • Dietary Supplements / adverse effects
  • Dietary Supplements / statistics & numerical data*
  • Humans
  • Male
  • Massachusetts / epidemiology
  • Muscle Strength / drug effects*
  • Neoplasms, Germ Cell and Embryonal / epidemiology*
  • Risk Factors
  • Testicular Neoplasms / epidemiology*

Supplementary concepts

  • Testicular Germ Cell Tumor