Prognostic Significance of Aberrant Methylation of Solute Carrier Gene Family 5A8 in Lung Adenocarcinoma

Ann Thorac Surg. 2015 May;99(5):1755-9. doi: 10.1016/j.athoracsur.2015.02.013. Epub 2015 Mar 29.


Background: Solute carrier family 5 member A8 (SLC5A8) is a sodium-coupled transporter for several chemicals. The SLC5A8 gene has been reported to function as a tumor suppressor gene that contributes to carcinogenesis and tumor progression. The expression of SLC5A8 is silenced in colon neoplasia by hypermethylation of CpG-rich islands located in exon 1. In this study, we assessed the significance of aberrant methylation of the SLC5A8 gene as a prognostic factor for lung adenocarcinoma (AD).

Methods: We analyzed the methylation levels of a consecutive series of 143 node-negative stage I and II lung AD samples using pyrosequencing.

Results: The methylation level of exon 1 in the SLC5A8 gene was significantly associated with poor prognosis in cases of node-negative stage I and II lung AD.

Conclusions: Gene silencing of SLC5A8 by hypermethylation was associated with poor prognosis in cases of node-negative stage I and II lung AD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / genetics*
  • Adenocarcinoma / surgery
  • Adenocarcinoma of Lung
  • Aged
  • Aged, 80 and over
  • Cation Transport Proteins / genetics*
  • Cation Transport Proteins / metabolism
  • Cohort Studies
  • DNA Methylation / physiology*
  • Female
  • Gene Silencing
  • Genes, Tumor Suppressor
  • Humans
  • Lung Neoplasms / genetics*
  • Lung Neoplasms / surgery
  • Male
  • Middle Aged
  • Monocarboxylic Acid Transporters
  • Neoplasm Staging
  • Prognosis


  • Cation Transport Proteins
  • Monocarboxylic Acid Transporters
  • SLC5A8 protein, human