Surveillance of short-segment Barrett's esophagus using ultrathin transnasal endoscopy

J Gastroenterol Hepatol. 2015 Mar;30 Suppl 1:41-5. doi: 10.1111/jgh.12879.

Abstract

Background and aim: Newly developed ultrathin transnasal endoscope, the GIF-XP290N, makes possible a resolving power similar to the GIF-H260 at a distance of 3 mm. We conducted surveillance of subjects with Barrett's esophagus using this ultrathin transnasal endoscopy. In Japan the lower margin of the lower esophageal palisade vessels is defined the gastroesophageal junction in deep inspiration. We diagnose Barrett's esophagus if columnar epithelium is present on the oral side of the gastroesophageal junction.

Methods and results: Barrett's esophagus was confirmed in 116 out of 135 subjects (85.9%), with 17 cases of short-segment Barrett's esophagus (SSBE) and 99 of ultra-short-segment Barrett's esophagus. Close observation of the Barrett's esophagus mucosal structural pattern using narrow band imaging revealed 29 cases with an oval or round pattern, 29 with a long straight pattern, 47 with a villous pattern, 8 with a cerebriform pattern, and 6 with an irregular pattern according to Goda classification. Mucosal biopsies from all subjects with SSBE are examined. Histological examination revealed intestinal metaplasia in only eight subjects. We grouped the oval/round and long straight patterns as closed type, and the villous, cerebriform, and irregular patterns as open type. Analysis of the relationship between these mucosal patterns and background factors revealed a significant correlation between intestinal metaplasia and the open-type pattern.

Conclusion: We consider this new ultrathin transnasal endoscopy to be a useful technique for surveillance of Barrett's esophagus, especially SSBE.

Keywords: Barrett's esophagus; Narrow band imaging; close examination; mucosal structure; transnasal endoscopy.

MeSH terms

  • Aged
  • Barrett Esophagus / diagnosis*
  • Barrett Esophagus / pathology
  • Endoscopy, Gastrointestinal / instrumentation*
  • Endoscopy, Gastrointestinal / methods
  • Esophagus / pathology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mucous Membrane / pathology
  • Prospective Studies