Approach to chemotherapy-associated thrombosis

Vasc Med. 2015 Apr;20(2):153-61. doi: 10.1177/1358863X14568705.

Abstract

Treatment of cancer patients with antineoplastic agents is associated with a heightened risk of thrombotic events, both arterial and venous. In this article, we review the specific agents that are implicated and the pathophysiological processes that are known to be associated with this prothrombotic state. We conclude with current recommendations for prophylactic antithrombotic therapy in these clinical situations.

Keywords: angiogenesis inhibitors; anticoagulants; endothelial cells; pulmonary embolism; review; thromboembolism; thrombosis; venous thrombosis.

Publication types

  • Review

MeSH terms

  • Anticoagulants / therapeutic use*
  • Antineoplastic Agents / adverse effects*
  • Humans
  • Neoplasms / complications
  • Pulmonary Embolism / drug therapy*
  • Thromboembolism / drug therapy*
  • Thrombosis / chemically induced*

Substances

  • Anticoagulants
  • Antineoplastic Agents