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. 2015 Jun;42(6):988-93.
doi: 10.3899/jrheum.141091. Epub 2015 Apr 1.

Clinical Trials Perception in Rheumatology Patients: Experience From a Single Rheumatology Tertiary Center

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Clinical Trials Perception in Rheumatology Patients: Experience From a Single Rheumatology Tertiary Center

Coziana Ciurtin et al. J Rheumatol. .

Abstract

Objective: To investigate the perception and willingness of rheumatology patients to participate in clinical trials. No previous similar studies are available.

Methods: We conducted a cross-sectional survey of rheumatology patients using a questionnaire, which comprised 2 demographic questions, two 5-point Likert opinion questions, 19 true/false/unsure knowledge questions, and 1 open question addressing what would help the participant to gain a better understanding about clinical trials.

Results: Eighty-five patients returned the questionnaires (response rate 84.1%). The mean number of correct answers to the 19 knowledge questions was 10.5 ± 2.87. Patients with higher versus lower levels of education had significantly higher knowledge scores (mean correct answers 59.4 ± 13.1 vs 39.8 ± 20.4, p = 0.013). They also expressed greater willingness to take part in research (87.5% vs 48.2%, p < 0.001). The patients who agreed to participate in research provided significantly more correct answers (59.4 ± 15.3% vs 47.7 ± 27.2%, p = 0.032). Poor disease control as the main reason to join a clinical trial correlated well with patients' previous participation in research (r = 0.71; p < 0.05) and the lack of understanding of research principles (defined as less than 50% correct answers to the knowledge questions) correlated with the lack of willingness to participate in clinical trials (r = 0.72; p < 0.05).

Conclusion: The results of our study revealed that patients lack information about clinical trials (the correct response rate was only slightly above 50%), and that they had a moderate willingness to take part in clinical trials. The need for educational programs about clinical research was highlighted by the participants to the survey.

Keywords: CLINICAL TRIALS; PATIENT EDUCATION; QUESTIONNAIRE.

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