L-ascorbic acid addition to chitosan reduces body weight in overweight women

Int J Vitam Nutr Res. 2014;84(1-2):5-11. doi: 10.1024/0300-9831/a000187.


Previously, we have found that the addition of L-ascorbic acid to chitosan enhanced the reduction in body weight gain in guinea pigs fed a high-fat diet. We hypothesized that the addition of L-ascorbic acid to chitosan would accelerate the reduction of body weight in humans, similar to the animal model. Overweight subjects administered chitosan with or without L-ascorbic acid for 8 weeks, were assigned to three groups: Control group (N=26, placebo, vehicle only), Chito group (N=27, 3 g/day chitosan), and Chito-vita group (N=27, 3 g/day chitosan plus 2 g/day L-ascorbic acid). The body weights and body mass index (BMI) of the Chito and Chito-vita groups decreased significantly (p<0.05) compared to the Control group. The BMI of the Chito-vita group decreased significantly compared to the Chito group (Chito: -1.0 kg/m2 vs. Chito-vita: -1.6 kg/m2, p<0.05). The results showed that the chitosan enhanced reduction of body weight and BMI was accentuated by the addition of L-ascorbic acid. The fat mass, percentage body fat, body circumference, and skinfold thickness in the Chito and Chito-vita groups decreased more than the Control group; however, these parameters were not significantly different between the three groups. Chitosan combined with L-ascorbic acid may be useful for controlling body weight.

Keywords: L-ascorbic acid; chitosan; dietary supplements; obesity; weight loss.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Ascorbic Acid / administration & dosage*
  • Basal Metabolism
  • Body Composition
  • Body Mass Index
  • Body Weight / drug effects
  • Chitosan / administration & dosage*
  • Dietary Carbohydrates / administration & dosage
  • Dietary Fats / administration & dosage
  • Dietary Proteins / administration & dosage
  • Dietary Supplements
  • Double-Blind Method
  • Energy Intake
  • Female
  • Humans
  • Lipids / blood
  • Overweight / drug therapy*
  • Placebos
  • Skinfold Thickness
  • Waist Circumference / drug effects
  • Weight Loss / drug effects*
  • Young Adult


  • Dietary Carbohydrates
  • Dietary Fats
  • Dietary Proteins
  • Lipids
  • Placebos
  • Chitosan
  • Ascorbic Acid