Matrix Metalloproteinase-9 as a Novel Player in Synaptic Plasticity and Schizophrenia

Schizophr Bull. 2015 Sep;41(5):1003-9. doi: 10.1093/schbul/sbv036. Epub 2015 Apr 2.


Recent findings implicate alterations in glutamate signaling, leading to aberrant synaptic plasticity, in schizophrenia. Matrix metalloproteinase-9 (MMP-9) has been shown to regulate glutamate receptors, be regulated by glutamate at excitatory synapses, and modulate physiological and morphological synaptic plasticity. By means of functional gene polymorphism, gene responsiveness to antipsychotics and blood plasma levels MMP-9 has recently been implicated in schizophrenia. This commentary critically reviews these findings based on the hypothesis that MMP-9 contributes to pathological synaptic plasticity in schizophrenia.

Keywords: extracellular matrix; glutamate; synaptic plasticity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Humans
  • Matrix Metalloproteinase 9 / genetics
  • Matrix Metalloproteinase 9 / metabolism*
  • Neuronal Plasticity / physiology*
  • Receptors, Glutamate / metabolism*
  • Schizophrenia / genetics
  • Schizophrenia / metabolism*


  • Receptors, Glutamate
  • Matrix Metalloproteinase 9