Pd(II)-catalyzed P(O)R(1)R(2)-directed asymmetric C-H activation and dynamic kinetic resolution for the synthesis of chiral biaryl phosphates

Org Lett. 2015 Apr 17;17(8):2034-7. doi: 10.1021/acs.orglett.5b00844. Epub 2015 Apr 2.

Abstract

An efficient method of Pd(II)-catalyzed P(O)R(1)R(2)-directed asymmetric C-H activation and dynamic kinetic resolution for synthesis of chiral phosphinate ligands has been performed and exhibits a wide scope of substrates and an excellent diastereomeric ratio (>95:5).