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. 2015 Mar;127(3):332-8.
doi: 10.1016/j.jphs.2015.01.008. Epub 2015 Feb 7.

Anti-tumor Effect of α-Pinene on Human Hepatoma Cell Lines Through Inducing G2/M Cell Cycle Arrest

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Anti-tumor Effect of α-Pinene on Human Hepatoma Cell Lines Through Inducing G2/M Cell Cycle Arrest

Weiqiang Chen et al. J Pharmacol Sci. .
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Abstract

Pine needle oil from crude extract of pine needles has been used as an anti-cancer agent in Traditional Chinese Medicine. The α-pinene is a natural compound isolated from pine needle oil which has been shown anti-cancer activity. In previous study, we found that pine needle oil exhibited significant inhibitory effect on hepatoma carcinoma BEL-7402 cells. In this study, we investigate the inhibition of α-pinene on hepatoma carcinoma BEL-7402 cells in vitro and in vivo and further explore the mechanism. The results show that liver cancer cell growth was inhibited obviously with inhibitory rate of 79.3% in vitro and 69.1% in vivo, Chk1 and Chk2 levels were upregulated, CyclinB, CDC25 and CDK1 levels were downregulated.

Keywords: BEL-7402 cells; In vitro and in vivo; Liver cancer; Mechanism; α-Pinene.

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