Concomitant trimodality therapy of re-irradiation, chemotherapy and regional hyperthermia for a pretreated inoperable sarcoma recurrence

Tumori. 2015 Mar-Apr;101(2):e54-6. doi: 10.5301/tj.5000250.

Abstract

We hereby present a case of pre-treated unresectable sarcoma recurrence of the trunk which showed an excellent response to concomitant tri-modal therapy, consisting of re-irradiation, chemotherapy and regional hyperthermia even with a strong compromised re-irradiation dose. No significant toxicity of the combined therapy and fast achievement of the pain and neurological symptoms relief are reported. The case shows that concurrent tri-modality treatment can be considered as a therapeutic option for the management of pre-treated unresectable recurrence even in there-irradiation setting.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Agents, Alkylating / administration & dosage
  • Antineoplastic Agents, Alkylating / therapeutic use*
  • Back Pain / etiology
  • Bone Neoplasms / secondary
  • Bone Neoplasms / therapy*
  • Chemoradiotherapy*
  • Diagnosis, Differential
  • Dose Fractionation, Radiation
  • Drug Administration Schedule
  • Female
  • Histiocytoma, Malignant Fibrous / complications
  • Histiocytoma, Malignant Fibrous / diagnosis
  • Histiocytoma, Malignant Fibrous / therapy*
  • Humans
  • Hyperthermia, Induced*
  • Ifosfamide / administration & dosage
  • Ifosfamide / therapeutic use*
  • Infusions, Intravenous
  • Magnetic Resonance Imaging
  • Middle Aged
  • Muscle Neoplasms / complications
  • Muscle Neoplasms / diagnosis
  • Muscle Neoplasms / therapy*
  • Neoplasm Recurrence, Local / complications
  • Neoplasm Recurrence, Local / diagnosis
  • Neoplasm Recurrence, Local / therapy*
  • Neoplasm Staging
  • Patient Satisfaction
  • Quality of Life
  • Radiotherapy, Image-Guided*
  • Retreatment
  • Thoracic Vertebrae*
  • Tomography, X-Ray Computed
  • Treatment Outcome

Substances

  • Antineoplastic Agents, Alkylating
  • Ifosfamide