Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Apr 3;348(6230):56-61.
doi: 10.1126/science.aaa8172.

The Future of Immune Checkpoint Therapy

Affiliations
Review

The Future of Immune Checkpoint Therapy

Padmanee Sharma et al. Science. .

Abstract

Immune checkpoint therapy, which targets regulatory pathways in T cells to enhance antitumor immune responses, has led to important clinical advances and provided a new weapon against cancer. This therapy has elicited durable clinical responses and, in a fraction of patients, long-term remissions where patients exhibit no clinical signs of cancer for many years. The way forward for this class of novel agents lies in our ability to understand human immune responses in the tumor microenvironment. This will provide valuable information regarding the dynamic nature of the immune response and regulation of additional pathways that will need to be targeted through combination therapies to provide survival benefit for greater numbers of patients.

Similar articles

See all similar articles

Cited by 959 articles

See all "Cited by" articles

Publication types

MeSH terms

Feedback