Phospholipase A2 Receptor and Sarcoidosis-Associated Membranous Nephropathy

Nephrol Dial Transplant. 2015 Jun;30(6):1047-50. doi: 10.1093/ndt/gfv080. Epub 2015 Apr 2.

Abstract

Of the glomerulonephritis associated with sarcoidosis, membranous nephropathy (MN) is the most prevalent. Coincidence or a causal relationship between these two diseases is unclear. Here, we present for the first time a high prevalence of PLA2R-related MN among patients with MN associated with active sarcoidosis. Our results suggest some causal link between sarcoidosis and PLA2R-related MN. Detection of anti-PLA2R antibodies in serum or PLA2R antigen in biopsy should not be taken as evidence against a secondary cause, particularly sarcoidosis. This important observation can affect treatment decision in these patients.

Keywords: membranous nephropathy; phospholipase A2 receptor; sarcoidosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antibodies, Anti-Idiotypic / blood*
  • Female
  • France / epidemiology
  • Glomerulonephritis, Membranous / blood
  • Glomerulonephritis, Membranous / diagnosis*
  • Glomerulonephritis, Membranous / epidemiology*
  • Humans
  • Male
  • Middle Aged
  • Prevalence
  • Prognosis
  • Receptors, Phospholipase A2 / blood
  • Receptors, Phospholipase A2 / immunology*
  • Retrospective Studies
  • Sarcoidosis / physiopathology*
  • Young Adult

Substances

  • Antibodies, Anti-Idiotypic
  • PLA2R1 protein, human
  • Receptors, Phospholipase A2