Low brain magnesium in migraine

Headache. 1989 Oct;29(9):590-3. doi: 10.1111/j.1526-4610.1989.hed2909590.x.


Brain magnesium was measured in migraine patients and control subjects using in vivo 31-Phosphorus Nuclear Magnetic Resonance Spectroscopy. pMg and pH were calculated from the chemical shifts between Pi, PCr and ATP signals. Magnesium levels were low during a migraine attack without changes in pH. We hypothesize that low brain magnesium is an important factor in the mechanism of the migraine attack.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Brain Chemistry*
  • Female
  • Humans
  • Magnesium / analysis*
  • Magnetic Resonance Spectroscopy
  • Male
  • Middle Aged
  • Migraine Disorders / diagnosis*
  • Phosphorus Radioisotopes


  • Phosphorus Radioisotopes
  • Magnesium