The Philadelphia Neurodevelopmental Cohort: A publicly available resource for the study of normal and abnormal brain development in youth

Theodore D Satterthwaite; John J Connolly; Kosha Ruparel; Monica E Calkins; Chad Jackson; Mark A Elliott; David R Roalf; Ryan Hopson; Karthik Prabhakaran; Meckenzie Behr; Haijun Qiu; Frank D Mentch; Rosetta Chiavacci; Patrick M A Sleiman; Ruben C Gur; Hakon Hakonarson; Raquel E Gur

doi:10.1016/j.neuroimage.2015.03.056

The Philadelphia Neurodevelopmental Cohort: A publicly available resource for the study of normal and abnormal brain development in youth

Neuroimage. 2016 Jan 1;124(Pt B):1115-1119. doi: 10.1016/j.neuroimage.2015.03.056. Epub 2015 Mar 31.

Authors

Theodore D Satterthwaite¹, John J Connolly², Kosha Ruparel³, Monica E Calkins³, Chad Jackson³, Mark A Elliott⁴, David R Roalf³, Ryan Hopson³, Karthik Prabhakaran³, Meckenzie Behr², Haijun Qiu², Frank D Mentch², Rosetta Chiavacci², Patrick M A Sleiman⁵, Ruben C Gur⁶, Hakon Hakonarson⁵, Raquel E Gur⁷

Affiliations

¹ Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: sattertt@upenn.edu.
² Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
³ Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
⁴ Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
⁵ Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
⁶ Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Philadelphia Veterans Administration Medical Center, Philadelphia, PA 19104, USA.
⁷ Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Abstract

The Philadelphia Neurodevelopmental Cohort (PNC) is a large-scale study of child development that combines neuroimaging, diverse clinical and cognitive phenotypes, and genomics. Data from this rich resource is now publicly available through the Database of Genotypes and Phenotypes (dbGaP). Here we focus on the data from the PNC that is available through dbGaP and describe how users can access this data, which is evolving to be a significant resource for the broader neuroscience community for studies of normal and abnormal neurodevelopment.

Keywords: Adolescence; Data-sharing; Development; MRI; Neuroimaging.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Brain / abnormalities*
Brain / growth & development*
Child
Child Development
Cognition
Developmental Disabilities / pathology*
Developmental Disabilities / psychology*
Female
Genomics
Humans
Information Dissemination*
Internet
Male
Nervous System / growth & development*
Neuroimaging

Abstract

Publication types

MeSH terms

Grants and funding