Previous studies have shown an inverse correlation between bone marrow adipose tissue and bone mineral density in cancellous bone; however, such relationships in cortical bone are less studied, especially in children. A total of 185 healthy children and adolescents (76 females and 109 males, aged 5-18 years) were included in this study. Right femoral bone marrow adipose tissue area (BMA), right femoral cortical bone area (CBA), subcutaneous adipose tissue, visceral adipose tissue, and skeletal muscle were accessed by whole-body magnetic resonance imaging. In regression analysis with CBA as the dependent variable and BMA as the independent variable, BMA negatively contributed to CBA after adjusting for weight and total body fat or subcutaneous adipose tissue, visceral adipose tissue, and skeletal muscle (β = -0.201 to -0.272, p < 0.001). These results suggest an inverse relationship between BMA and CBA in children and adolescents after adjustment of body weight or body composition. The data support the hypothesis that a competitive relationship exists between bone and marrow fat in cortical bone and is consistent with a similar finding in cancellous bone in previous studies. Future research is needed to clarify the role of marrow fat in childhood fractures that are related to cortical bone quality.
Keywords: Adolescents; body composition; bone marrow adipose tissue; children; cortical bone area; dual-energy X-ray absorptiometry; magnetic resonance imaging.
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