5-HT3 receptor antagonists for the treatment of nausea/vomiting

Ann Palliat Med. 2012 Jul;1(2):115-20. doi: 10.3978/j.issn.2224-5820.2012.07.07.


It is well appreciated that a number of things (e.g., various insults, chemotherapeutic agents, radiation) may lead to the release of serotonin from the enterochromaffin of the gastrointestinal tract. Released serotonin may then bind to certain 5-HT3 receptors and promote nausea/vomiting. 5-HT3 receptor antagonists may ameliorate nausea/vomiting in a number of circumstances and have been utilized as important antiemetics for multiple conditions such as chemotherapy-induced nausea/vomiting (CINV), radiation-induced emesis (RIS), and postoperative nausea/vomiting (PONV).

Keywords: 5-HT3 antagonists; Nausea/Vomiting; chemotherapy-induced nausea/vomiting; ondansetron; palonostron; postoperative nausea/vomiting; serotonin.