Abstract
Non-steroidal anti-inflammatory drugs influence the electromyogram of smooth muscle of ileum, the cecum and the ascending portion of the colon in rats during ulcerative colitis was investigated. It was shown that COX-2 inhibitors normalized the electromotor activity of ileo-ascendo complex, lowered infiltration of round cells in mucous-submucosal tissue and blood flow.
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
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Cecum / blood supply
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Cecum / drug effects*
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Cecum / physiopathology
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Colitis, Ulcerative / drug therapy*
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Colitis, Ulcerative / immunology
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Colitis, Ulcerative / physiopathology
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Colon, Ascending / blood supply
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Colon, Ascending / drug effects*
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Colon, Ascending / physiopathology
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Disease Models, Animal
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Dose-Response Relationship, Drug
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Electromyography
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Ileum / blood supply
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Ileum / drug effects*
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Ileum / physiopathology
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Muscle, Smooth / drug effects
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Muscle, Smooth / physiopathology
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Rats
Substances
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Anti-Inflammatory Agents, Non-Steroidal