Diabetic cardiomyopathy and the role of mitochondrial dysfunction: novel insights, mechanisms, and therapeutic strategies

Antioxid Redox Signal. 2015 Jun 10;22(17):1499-501. doi: 10.1089/ars.2015.6349. Epub 2015 Apr 29.


This Forum addresses the role of mitochondrial dysfunction in the multifactorial nature of diabetic cardiomyopathy (DCM) from multiple angles. Contributors deliver a diverse and in-depth view of the state-of-the-art in DCM, from bench to bedside. What emerges is a picture of mitochondrial dysfunction as a central upstream defect, inflicted on the heart by diabetes. Collectively, the authors pinpoint high-value knowledge gaps, propose new conceptual frameworks, and highlight understudied, but promising, research themes.

Publication types

  • Editorial

MeSH terms

  • Animals
  • Diabetes Complications / metabolism
  • Diabetes Complications / pathology
  • Diabetic Cardiomyopathies / physiopathology*
  • Diabetic Cardiomyopathies / therapy*
  • Humans
  • Mitochondria, Heart / metabolism*
  • Muscle, Skeletal / metabolism
  • Muscle, Skeletal / pathology
  • Myocardium / metabolism
  • Myocardium / pathology