Urticaria multiforme: A report of 5 cases and a review of the literature

Actas Dermosifiliogr. 2016 Jan-Feb;107(1):e1-5. doi: 10.1016/j.ad.2015.01.003. Epub 2015 Apr 3.
[Article in English, Spanish]


Urticaria multiforme is a cutaneous disorder that affects infants and small children. It is characterized by large, annular urticarial plaques with a violaceous center and is frequently accompanied by fever. Urticaria multiforme follows a benign, self-limiting course, but the striking appearance of the lesions can cause alarm and considerable anxiety among parents. We present 5 cases of urticaria multiforme seen in our hospital over a period of 18 months. All the cases were preceded by an infection of the upper airways or otitis, and they were all empirically with amoxicillin. It is important to be familiar with this condition to reassure parents and avoid unnecessary hospital admissions and tests.

Keywords: Eritema multiforme; Erythema multiforme; Infant; Niño; Urticaria.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Erythema Multiforme / diagnosis*
  • Erythema Multiforme / drug therapy
  • Female
  • Fever
  • Humans
  • Infant
  • Male
  • Urticaria / diagnosis*
  • Urticaria / drug therapy