CHILD Syndrome: Successful Treatment of Skin Lesions with Topical Simvastatin/Cholesterol Ointment--A Case Report

Pediatr Dermatol. 2015 Jul-Aug;32(4):e145-7. doi: 10.1111/pde.12587. Epub 2015 Apr 6.

Abstract

CHILD syndrome is a rare X-linked dominant condition that presents with congenital hemidysplasia, Ichthyosiform erythroderma, and limb defects in affected patients. We report the case of a 10-year-old girl treated with topical simvastatin and cholesterol ointment, after which her skin lesions significantly improved within the first 30 days of treatment.

Publication types

  • Case Reports

MeSH terms

  • Abnormalities, Multiple / drug therapy*
  • Administration, Topical
  • Anticholesteremic Agents / therapeutic use*
  • Child
  • Cholesterol / therapeutic use*
  • Female
  • Genetic Diseases, X-Linked / drug therapy*
  • Humans
  • Ichthyosiform Erythroderma, Congenital / drug therapy*
  • Lichenoid Eruptions / drug therapy
  • Lichenoid Eruptions / etiology
  • Limb Deformities, Congenital / drug therapy*
  • Lipid Metabolism, Inborn Errors / complications
  • Ointments
  • Simvastatin / therapeutic use*

Substances

  • Anticholesteremic Agents
  • Ointments
  • Cholesterol
  • Simvastatin

Supplementary concepts

  • Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects