Biomaterials for Bone Regenerative Engineering

Adv Healthc Mater. 2015 Jun 24;4(9):1268-85. doi: 10.1002/adhm.201400760. Epub 2015 Apr 7.


Strategies for bone tissue regeneration have been continuously evolving for the last 25 years since the introduction of the "tissue engineering" concept. The convergence of the life, physical, and engineering sciences has brought in several advanced technologies available to tissue engineers and scientists. This resulted in the creation of a new multidisciplinary field termed as "regenerative engineering". In this article, the role of biomaterials in bone regenerative engineering is systematically reviewed to elucidate the new design criteria for the next generation of biomaterials for bone regenerative engineering. The exemplary design of biomaterials harnessing various materials characteristics towards successful bone defect repair and regeneration is highlighted. Particular attention is given to the attempts of incorporating advanced materials science, stem cell technologies, and developmental biology into biomaterials design to engineer and develop the next generation bone grafts.

Keywords: biomaterials; bone; composites; osteogenesis; regenerative engineering.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Bone Regeneration*
  • Bone Substitutes / therapeutic use*
  • Humans
  • Regenerative Medicine / methods*
  • Regenerative Medicine / trends
  • Tissue Engineering / methods*
  • Tissue Engineering / trends


  • Bone Substitutes