Wine protein haze: mechanisms of formation and advances in prevention

J Agric Food Chem. 2015 Apr 29;63(16):4020-30. doi: 10.1021/acs.jafc.5b00047. Epub 2015 Apr 15.


Protein haze is an aesthetic problem in white wines that can be prevented by removing the grape proteins that have survived the winemaking process. The haze-forming proteins are grape pathogenesis-related proteins that are highly stable during winemaking, but some of them precipitate over time and with elevated temperatures. Protein removal is currently achieved by bentonite addition, an inefficient process that can lead to higher costs and quality losses in winemaking. The development of more efficient processes for protein removal and haze prevention requires understanding the mechanisms such as the main drivers of protein instability and the impacts of various wine matrix components on haze formation. This review covers recent developments in wine protein instability and removal and proposes a revised mechanism of protein haze formation.

Keywords: bentonite alternatives; chitinases; pathogenesis-related proteins; protease; protein aggregation; thaumatin-like protein; wine haze; wine heat instability; wine protein.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Food Technology
  • Humans
  • Plant Proteins / chemistry*
  • Protein Folding
  • Vitis / chemistry*
  • Wine / adverse effects*
  • Wine / analysis


  • Plant Proteins