Architecture of the cerebral cortical association connectome underlying cognition

Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E2093-101. doi: 10.1073/pnas.1504394112. Epub 2015 Apr 6.


Cognition presumably emerges from neural activity in the network of association connections between cortical regions that is modulated by inputs from sensory and state systems and directs voluntary behavior by outputs to the motor system. To reveal global architectural features of the cortical association connectome, network analysis was performed on >16,000 reports of histologically defined axonal connections between cortical regions in rat. The network analysis reveals an organization into four asymmetrically interconnected modules involving the entire cortex in a topographic and topologic core-shell arrangement. There is also a topographically continuous U-shaped band of cortical areas that are highly connected with each other as well as with the rest of the cortex extending through all four modules, with the temporal pole of this band (entorhinal area) having the most cortical association connections of all. These results provide a starting point for compiling a mammalian nervous system connectome that could ultimately reveal novel correlations between genome-wide association studies and connectome-wide association studies, leading to new insights into the cellular architecture supporting cognition.

Keywords: cerebral cortex; connectomics; mammal; network analysis; neural connections.

MeSH terms

  • Algorithms
  • Animals
  • Cerebral Cortex / physiology*
  • Cognition / physiology*
  • Connectome*
  • Humans
  • Nerve Net / physiology
  • Rats