Ginger-Mechanism of action in chemotherapy-induced nausea and vomiting: A review

Crit Rev Food Sci Nutr. 2017 Jan 2;57(1):141-146. doi: 10.1080/10408398.2013.865590.


Despite advances in antiemetic therapy, chemotherapy-induced nausea and vomiting (CINV) still poses a significant burden to patients undergoing chemotherapy. Nausea, in particular, is still highly prevalent in this population. Ginger has been traditionally used as a folk remedy for gastrointestinal complaints and has been suggested as a viable adjuvant treatment for nausea and vomiting in the cancer context. Substantial research has revealed ginger to possess properties that could exert multiple beneficial effects on chemotherapy patients who experience nausea and vomiting. Bioactive compounds within the rhizome of ginger, particularly the gingerol and shogaol class of compounds, interact with several pathways that are directly implicated in CINV in addition to pathways that could play secondary roles by exacerbating symptoms. These properties include 5-HT3, substance P, and acetylcholine receptor antagonism; antiinflammatory properties; and modulation of cellular redox signaling, vasopressin release, gastrointestinal motility, and gastric emptying rate. This review outlines these proposed mechanisms by discussing the results of clinical, in vitro, and animal studies both within the chemotherapy context and in other relevant fields. The evidence presented in this review indicates that ginger possesses multiple properties that could be beneficial in reducing CINV.

Keywords: CINV; Ginger; chemotherapy; nausea; vomiting.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / analysis
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Antiemetics / analysis
  • Antiemetics / chemistry
  • Antiemetics / therapeutic use*
  • Antineoplastic Agents / adverse effects*
  • Antioxidants / analysis
  • Antioxidants / chemistry
  • Antioxidants / therapeutic use
  • Catechols / analysis
  • Catechols / metabolism
  • Catechols / therapeutic use
  • Ethnopharmacology
  • Fatty Alcohols / analysis
  • Fatty Alcohols / metabolism
  • Fatty Alcohols / therapeutic use
  • Humans
  • Models, Biological*
  • Nausea / chemically induced
  • Nausea / metabolism
  • Nausea / physiopathology
  • Nausea / prevention & control*
  • Rhizome / chemistry*
  • Vomiting / chemically induced
  • Vomiting / metabolism
  • Vomiting / physiopathology
  • Vomiting / prevention & control*
  • Zingiber officinale / chemistry*


  • Anti-Inflammatory Agents, Non-Steroidal
  • Antiemetics
  • Antineoplastic Agents
  • Antioxidants
  • Catechols
  • Fatty Alcohols
  • shogaol
  • gingerol