Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter

Nat Rev Drug Discov. 2015 May;14(5):329-45. doi: 10.1038/nrd4433. Epub 2015 Apr 7.


Hydrogen sulfide (H2S) has become recognized as an important signalling molecule throughout the body, contributing to many physiological and pathological processes. In recent years, improved methods for measuring H2S levels and the availability of a wider range of H2S donors and more selective inhibitors of H2S synthesis have helped to more accurately identify the many biological effects of this highly reactive gaseous mediator. Animal studies of several H2S-releasing drugs have demonstrated considerable promise for the safe treatment of a wide range of disorders. Several such drugs are now in clinical trials.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Gasotransmitters / metabolism*
  • Humans
  • Hydrogen Sulfide / metabolism*
  • Molecular Targeted Therapy
  • Signal Transduction / physiology*


  • Gasotransmitters
  • Hydrogen Sulfide