PROVEAN web server: a tool to predict the functional effect of amino acid substitutions and indels

Bioinformatics. 2015 Aug 15;31(16):2745-7. doi: 10.1093/bioinformatics/btv195. Epub 2015 Apr 6.


We present a web server to predict the functional effect of single or multiple amino acid substitutions, insertions and deletions using the prediction tool PROVEAN. The server provides rapid analysis of protein variants from any organisms, and also supports high-throughput analysis for human and mouse variants at both the genomic and protein levels.

Availability and implementation: The web server is freely available and open to all users with no login requirements at


Supplementary information: Supplementary data are available at Bioinformatics online.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Amino Acid Substitution / genetics*
  • Animals
  • Genetic Variation
  • Genome
  • Humans
  • INDEL Mutation / genetics*
  • Internet*
  • Mice
  • Proteins / chemistry
  • Proteins / genetics
  • Sequence Deletion
  • Software*


  • Proteins