Lysophosphatidic acid signalling in development

Development. 2015 Apr 15;142(8):1390-5. doi: 10.1242/dev.121723.


Lysophosphatidic acid (LPA) is a bioactive phospholipid that is present in all tissues examined to date. LPA signals extracellularly via cognate G protein-coupled receptors to mediate cellular processes such as survival, proliferation, differentiation, migration, adhesion and morphology. These LPA-influenced processes impact many aspects of organismal development. In particular, LPA signalling has been shown to affect fertility and reproduction, formation of the nervous system, and development of the vasculature. Here and in the accompanying poster, we review the developmentally related features of LPA signalling.

Keywords: Adhesion; Chemotaxis; Differentiation; GPCR; Lysophospholipid; Migration; Progenitor; Proliferation; Survival; Trafficking.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Movement / physiology
  • Humans
  • Lysophospholipids / metabolism*
  • Nervous System / metabolism
  • Receptors, G-Protein-Coupled / metabolism
  • Reproduction / physiology
  • Signal Transduction / physiology


  • Lysophospholipids
  • Receptors, G-Protein-Coupled
  • lysophosphatidic acid