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, 110 (4), 604-6

Serial Fecal Microbiota Transplantation Alters Mucosal Gene Expression in Pediatric Ulcerative Colitis

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Serial Fecal Microbiota Transplantation Alters Mucosal Gene Expression in Pediatric Ulcerative Colitis

Richard Kellermayer et al. Am J Gastroenterol.

Conflict of interest statement

Conflict of Interest: Potential competing interests: None.

Figures

Figure 1
Figure 1
Fecal microbiota shifts following fecal microbiota transplantation (FMT). Principle coordinates analysis of unweighted Unifrac distances (a) revealed that microbial community changes during FMT (arrows connect pre-FMT (within 24 h before first FMT) and post-FMT (2–3 weeks after last FMT) samples from each patient) were not consistent within each patient (did not shift in the same direction for each patient), and post-FMT fecal communities of recipients (patients) following FMT were dissimilar from that of the donor (▲: donor stool; ■: donor preparations from independent bowel movements on separate days). Microbial richness (b) and diversity (c) in terms of microbial taxa consistently increased following the FMT, although these trends did not reach statistical significance. OTU, operational taxonomic units.

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