Serum selenium and ceruloplasmin in nigerians with peripartum cardiomyopathy

Int J Mol Sci. 2015 Apr 7;16(4):7644-54. doi: 10.3390/ijms16047644.


The study aimed to determine if selenium deficiency, serum ceruloplasmin and traditional birth practices are risk factors for peripartum cardiomyopathy (PPCM), in Kano, Nigeria. This is a case-control study carried out in three hospitals, and PPCM patients were followed up for six months. Critically low serum selenium concentration was defined as <70 µg/L. A total of 39 PPCM patients and 50 controls were consecutively recruited after satisfying the inclusion criteria. Mean serum selenium in patients (61.7 ± 14.9 µg/L) was significantly lower than in controls (118.4 ± 45.6 µg/L) (p < 0.001). The prevalence of serum selenium <70 µg/L was significantly higher among patients (76.9%) than controls (22.0%) (p < 0.001). The mean ceruloplasmin and prevalence of socio-economic indices, multiparity, pregnancy-induced hypertension, obesity and twin pregnancy were not different between the groups (p > 0.05). Logistic regression showed that rural residency significantly increased the odds for serum selenium <70 µg/L by 2.773-fold (p = 0.037). Baseline serum levels of selenium and ceruloplasmin were not associated with six-month mortality. This study has shown that selenium deficiency is a risk factor for PPCM in Kano, Nigeria, and is related to rural residency. However, serum ceruloplasmin, customary birth practices and some other characteristics were not associated with PPCM in the study area.

Publication types

  • Multicenter Study

MeSH terms

  • Adult
  • Cardiomyopathies / blood
  • Cardiomyopathies / enzymology
  • Cardiomyopathies / etiology*
  • Case-Control Studies
  • Ceruloplasmin / metabolism*
  • Female
  • Humans
  • Nigeria
  • Peripartum Period / blood*
  • Rural Population
  • Selenium / blood
  • Selenium / deficiency*
  • Socioeconomic Factors
  • Young Adult


  • Ceruloplasmin
  • Selenium