Creatine supplementation alters homocysteine level in resistance trained men

J Sports Med Phys Fitness. 2015 Apr;55(4):313-9.


Aim: This study was conducted to investigate the effects of creatine loading and resistance training on the homocysteine and lipid profiles of young males.

Method: Sixty male University students (22.34 ± 2.19 years, 1.79 ± 0.08 m, 77.18 ± 12.57 kg, 15.48 ± 4.57% body fat) were randomly divided in to three groups; control (CG=20), creatine supplement (CEG=20) and placebo (PEG=20). Both CEG and PEG participated in a same resistance-training regimen and either taking a creatine supplement (25 g/d for the first 5 days followed 5 g/d thereafter) or the same amount of placebo for 8 weeks. Participants in CG did not take any creatine supplementation and not engage any exercise program. After the body composition were assessed, the homocysteine (Hcy) concentrations, blood lipids, folic acid and vitamin B12 levels of all the participants were measured at the beginning and end of the eight weeks of resistance training.

Results: The analysis of the data indicated that the Hcy levels of the CEG after resistance training and receiving the creatine supplement (9.33 ± 4.60) was significantly lower than that of baseline (12.66 ± 5.89) measurements, F(1,18)=12.28, P=0.00. No significant differences were seen in the Hcy levels of the PEG (15.01 ± 10.87) after 8 weeks of training and receiving a placebo (12.46 ± 12.50), F(1,16)=4.65, P=0.05. Furthermore, there were no significant differences among groups in terms of Hcy levels, F(2,52)=1.72, P=0.19.

Conclusion: The present study suggests that as well as strength gain; creatine supplementation with resistance training may afford some protection against emerging cardiovascular risk factors.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Creatine / administration & dosage*
  • Dietary Supplements*
  • Double-Blind Method
  • Homocysteine / blood*
  • Humans
  • Male
  • Resistance Training*
  • Young Adult


  • Homocysteine
  • Creatine