The article covers data on oxidative activity in cellular DNA, on cytogenetic effects, on sexual hormones levels under exposure to chemical hazards in female workers of dyeboard fabric preparation industry. Findings are that in such occupations as bleacher, mercerization and glazing operator, chemical solutions and dyes. supplier, flushing equipment operator demonstrate the highest serum levels of manganese, lead, toluene and xylene vs. the reference group parameters (1.5-1.8 times) due to occupational hazards. Significant differences were seen between the groups of exposed and unexposed workers in parameters characterizing negative effects development: higher activity of DNA oxidation products formation (according to increased urinary level of 8-OHdG), higher prevalence and variability of chromosomal polymorphism characterizing genetic instability of somatic cells, disbalance of sexual hormones (according to increased serum prolactine and lower FSH). These processes can result in functional disorders of pelvic organs, with increased prevalence of hormone-dependent gynecologic diseases in the female workers and remote effects in the offspring.