CD45 antigen negativity in T-lineage ALL correlates with PTPRC mutation and sensitivity to a selective JAK inhibitor

Br J Haematol. 2015 Dec;171(5):884-7. doi: 10.1111/bjh.13448. Epub 2015 Apr 8.
No abstract available

Keywords: CD45 antigen; JAK1 mutation; PTPRC mutation; T-lineage acute lymphoblastic leukaemia; target therapy.

Publication types

  • Case Reports
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / therapeutic use
  • Humans
  • Janus Kinase 1 / antagonists & inhibitors*
  • Leukemia-Lymphoma, Adult T-Cell / drug therapy*
  • Leukemia-Lymphoma, Adult T-Cell / genetics
  • Leukocyte Common Antigens / deficiency*
  • Leukocyte Common Antigens / genetics
  • Male
  • Middle Aged
  • Mutation / genetics*
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Pyrazoles / therapeutic use

Substances

  • Antineoplastic Agents
  • INCB018424
  • Pyrazoles
  • JAK1 protein, human
  • Janus Kinase 1
  • Leukocyte Common Antigens
  • PTPRC protein, human