Association of early maternal hypertriglyceridemia with pregnancy-induced hypertension

Arch Gynecol Obstet. 2015 Nov;292(5):1135-43. doi: 10.1007/s00404-015-3706-1. Epub 2015 Apr 9.

Abstract

Background: Hypertensive diseases are directly responsible for 24 % of maternal deaths in India. A screening method is yet to be discovered to reduce the morbidity and mortality related to it. Serum triglyceride (TG) levels are reported to increase in hypertensive pregnant women.

Aim: To predict pregnancy-induced hypertension (PIH) by serum triglyceride values.

Method: This study is a prospective cohort study that was conducted over three hundred normotensive, primigravida women with singleton pregnancy at 14-20 weeks of gestation. These were divided into two groups on the basis of their TG concentration estimated at 14-20 weeks of gestation. The pregnancy was then followed till delivery and, signs and symptoms of PIH were noted in both the groups.

Results: Out of 300 women, 210 women completed the study. Fifty-nine women developed PIH and 151 women remained normotensive. Among 59 women, 45 women had raised TG values i.e., ≥160 mg/dL and 14 women were with normal TG levels i.e., <160 mg/dL. A significant positive correlation was found between serum TG concentration and systolic and diastolic blood pressure. It was observed that a cutoff of 162.50 mg/dL for TG could reliably predict PIH with sensitivity of 76 % and specificity of 85 %. Also, the mothers with hypertriglyceridemia were found to be at higher risk of developing early-onset PIH.

Conclusion: Our study supports the evidence that early pregnancy hypertriglyceridemia is associated with an increased risk of PIH.

Keywords: Early pregnancy; Hypertensive disorder of pregnancy; Hypertriglyceridemia; Pregnancy induced hypertension; Serum triglyceride level.

MeSH terms

  • Adult
  • Blood Pressure / physiology
  • Cohort Studies
  • Female
  • Humans
  • Hypertension, Pregnancy-Induced / blood*
  • Hypertension, Pregnancy-Induced / etiology
  • Hypertension, Pregnancy-Induced / physiopathology
  • Hypertriglyceridemia / blood*
  • Hypertriglyceridemia / complications
  • India
  • Pregnancy
  • Prospective Studies
  • Time Factors