Cell Autonomous and Non-Autonomous Effects of Senescent Cells in the Skin

J Invest Dermatol. 2015 Jul;135(7):1722-1726. doi: 10.1038/jid.2015.108. Epub 2015 Apr 9.


Human and mouse skin accumulate senescent cells in both the epidermis and dermis during aging. When chronically present, senescent cells are thought to enhance the age-dependent deterioration of the skin during extrinsic and intrinsic aging. However, when transiently present, senescent cells promote optimal wound healing. Here, we review recent studies on how senescent cells and the senescence-associated secretory phenotype contribute to different physiological and pathophysiological conditions in the skin with a focus on some of the cell autonomous and non-autonomous functions of senescent cells in the context of skin aging and wound healing.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Division
  • Cellular Senescence / genetics
  • Cellular Senescence / physiology*
  • Epidermal Cells*
  • Epidermis / physiology*
  • Female
  • Fibroblasts / cytology
  • Fibroblasts / physiology
  • Homeostasis / genetics
  • Homeostasis / physiology*
  • Humans
  • Male
  • Mice
  • Sensitivity and Specificity
  • Skin / cytology
  • Skin / metabolism
  • Skin Aging / physiology*
  • Wound Healing / physiology*