[Properties and biological roles of TET proteins during embryogenesis and in hematopoiesis]

Med Sci (Paris). 2015 Mar;31(3):268-74. doi: 10.1051/medsci/20153103012. Epub 2015 Apr 8.
[Article in French]

Abstract

DNA methylation is associated with a large number of biological processes and mainly concerns the cytosine methylation at position 5 (5-mC). An active demethylation mechanism was highlighted in 2009 following the discovery that TET proteins were enzymes implicated in the hydroxylation of 5-mC to 5-hydroxymethylcytosine. Simultaneously, other studies showed frequent acquired TET2 mutations in hematological malignancies and have depicted their role in their pathogenesis. An entire field of research has developed rapidly showing that these proteins are involved in many biological processes.

Publication types

  • Review

MeSH terms

  • Animals
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology*
  • Dioxygenases / chemistry
  • Dioxygenases / genetics
  • Dioxygenases / physiology*
  • Embryonic Development / genetics*
  • Gene Expression Regulation, Developmental
  • Hematopoiesis / genetics*
  • Humans
  • Mixed Function Oxygenases
  • Proto-Oncogene Proteins / chemistry
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins / physiology*

Substances

  • DNA-Binding Proteins
  • Proto-Oncogene Proteins
  • Mixed Function Oxygenases
  • TET1 protein, human
  • TET3 protein, human
  • Dioxygenases
  • TET2 protein, human