Paraspinal Muscle Spindle Response to Intervertebral Fixation and Segmental Thrust Level During Spinal Manipulation in an Animal Model

Spine (Phila Pa 1976). 2015 Jul 1;40(13):E752-9. doi: 10.1097/BRS.0000000000000915.

Abstract

Study design: In vivo cat model study.

Objective: To determine whether intervertebral facet joint fixation and segmental thrust level alter paraspinal muscle spindle activity during simulated spinal manipulation.

Summary of background data: Intervertebral motion is commonly assessed by manual therapy practitioners during clinical evaluation and treatment. Mechanoreceptor activity elicited during spinal manipulation has been theorized as a potential mechanism of its efficacy. The degree to which intervertebral fixation and segmental thrust level alter paraspinal muscle spindle activity during high velocity low amplitude spinal manipulation (HVLA-SM) is unclear.

Methods: Intervertebral fixation was created by inserting facet screws through the left L(5-6) and L(6-7) and left L(4-5), L(5-6), and L(6-7) facet joints of a cat spine. Changes in the mean instantaneous frequency of L6 muscle spindle discharge were determined during 5 HVLA-SM thrust durations (0-control, 75, 100, 150, 250 ms) delivered at the L4 or L6 spinous process in each of the 3 conditions within the same preparation: laminectomy-only (surgical control; n = 23), L(5-6) and L(6-7) fixations (n = 20), and L(4-5), L(5-6), and L(6-7) fixations (n = 7). Comparisons were made between thrust levels, thrust durations, and spinal joint conditions using a linear mixed model.

Results: Insertion of facet screws compared with laminectomy-only significantly increased (P < 0.001) lumbar spinal stiffness during L6 HVLA-SM. Compared with laminectomy-only, both the 2 facet screw (100 ms; P < 0.05) and 3 screw conditions [75 ms and 100 ms (P < 0.001), 150 ms (P < 0.005), and 250 ms (P < 0.05)] significantly decreased L6 spindle response during the L6 HVLA-SM. HVLA-SM-delivered 2 segments rostral to the level of muscle spindle input significantly decreases spindle response compared with HVLA-SM-delivered at-level; however, nontarget HVLA-SM still elicits 60% to 80% of at-level muscle spindle response.

Conclusion: Intervertebral fixation decreases paraspinal muscle spindle response during L6 HVLA-SM in a cat model. Whereas HVLA-SM target accuracy maximizes spindle response, nontarget HVLA-SM still elicits substantial levels of muscle spindle activity.

Level of evidence: N/A.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Action Potentials
  • Animals
  • Biomechanical Phenomena
  • Bone Screws
  • Cats
  • Electric Stimulation
  • Laminectomy
  • Linear Models
  • Lumbar Vertebrae / physiopathology
  • Lumbar Vertebrae / surgery*
  • Male
  • Manipulation, Spinal*
  • Models, Animal
  • Paraspinal Muscles / innervation*
  • Range of Motion, Articular
  • Spinal Fusion* / instrumentation
  • Time Factors
  • Zygapophyseal Joint / physiopathology
  • Zygapophyseal Joint / surgery*