Biomechanical and bioactivity concepts of polyetheretherketone composites for use in orthopedic implants-a review

J Biomed Mater Res A. 2015 Nov;103(11):3689-702. doi: 10.1002/jbm.a.35480. Epub 2015 Apr 28.


The use of polyetheretherketone (PEEK) composites in the trauma plating system, total replacement implants, and tissue scaffolds has found great interest among researchers. In recent years (2008 afterward), this type of composites has been examined for suitability as substitute material over stainless steel, titanium alloys, ultra high molecular weight polyethylene, or even biodegradable materials in orthopedic implant applications. Biomechanical and bioactivity concepts were contemplated for the development of PEEK orthopedic implants and a few primary clinical studies reported the clinical outcomes of PEEK-based orthopedic implants. This study aims to review and discuss the recent concepts and contribute further concepts in terms of biomechanical and bioactivity challenges for the development of PEEK and PEEK composites in orthopedic implants.

Keywords: bioactivity; biomechanical; orthopedic implants; polyetheretherketone.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Benzophenones
  • Biocompatible Materials / pharmacology*
  • Biomechanical Phenomena / drug effects
  • Humans
  • Ketones / pharmacology*
  • Orthopedics*
  • Polyethylene Glycols / pharmacology*
  • Polymers
  • Prostheses and Implants*


  • Benzophenones
  • Biocompatible Materials
  • Ketones
  • Polymers
  • polyetheretherketone
  • Polyethylene Glycols