Macrophages and Therapeutic Resistance in Cancer

Cancer Cell. 2015 Apr 13;27(4):462-72. doi: 10.1016/j.ccell.2015.02.015. Epub 2015 Apr 6.

Abstract

How neoplastic cells respond to therapy is not solely dependent on the complexity of the genomic aberrations they harbor but is also regulated by numerous dynamic properties of the tumor microenvironment. Identifying and targeting critical pathways that improve therapeutic efficacy by bolstering anti-tumor immune responses holds great potential for improving outcomes and impacting long-term patient survival. Macrophages are key regulators of homeostatic tissue and tumor microenvironments. Therefore, therapeutics impacting macrophage presence and/or bioactivity have shown promise in preclinical models and are now being evaluated in the clinic. This review discusses the molecular/cellular pathways identified so far whereby macrophages mediate therapeutic responses.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Drug Resistance, Neoplasm
  • Humans
  • Immunity, Cellular
  • Immunotherapy
  • Macrophages / drug effects
  • Macrophages / immunology*
  • Mice
  • Models, Immunological
  • Neoplasm Metastasis / immunology
  • Neoplasm Metastasis / therapy
  • Neoplasms / immunology
  • Neoplasms / pathology
  • Neoplasms / therapy*
  • Neovascularization, Pathologic / immunology
  • Neovascularization, Pathologic / therapy
  • Tumor Microenvironment*