The natural compound chebulagic acid inhibits vascular endothelial growth factor A mediated regulation of endothelial cell functions

Sci Rep. 2015 Apr 10;5:9642. doi: 10.1038/srep09642.

Abstract

Vascular endothelial growth factor A (VEGFA) plays an important role in tumour angiogenesis and its angiogenic action is mainly mediated through its VEGF receptor 2 (VEGFR-2). Therefore drugs targeting VEGFA/VEGFR-2 are being presently used in the clinics for treatment of several types of solid malignant tumours. We here in report that low dose of chebulagic acid (CA), a hydrolysable tannin found in myrobalan fruits can inhibit VEGFA induced vascular permeability, endothelial cell proliferation, migration, tube formation and thereby, angiogenesis by suppressing VEGFR-2 phosphorylation. CA may thus be an effective and useful natural inhibitor of VEGFA mediated angiogenesis.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Benzopyrans / pharmacokinetics
  • Benzopyrans / pharmacology*
  • Biological Products / pharmacokinetics
  • Biological Products / pharmacology*
  • Cell Movement / drug effects
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Chickens
  • Endothelial Cells / drug effects*
  • Endothelial Cells / metabolism*
  • Glucosides / pharmacokinetics
  • Glucosides / pharmacology*
  • Human Umbilical Vein Endothelial Cells
  • Humans
  • Mice
  • Neovascularization, Physiologic / drug effects
  • Permeability / drug effects
  • Phosphorylation
  • Plant Extracts / administration & dosage
  • Vascular Endothelial Growth Factor A / metabolism*
  • Vascular Endothelial Growth Factor Receptor-2 / metabolism

Substances

  • Benzopyrans
  • Biological Products
  • Glucosides
  • Plant Extracts
  • Vascular Endothelial Growth Factor A
  • triphala
  • chebulagic acid
  • Vascular Endothelial Growth Factor Receptor-2