Emotion-motion interactions in conversion disorder: an FMRI study

PLoS One. 2015 Apr 10;10(4):e0123273. doi: 10.1371/journal.pone.0123273. eCollection 2015.


Objectives: To evaluate the neural correlates of implicit processing of negative emotions in motor conversion disorder (CD) patients.

Methods: An event related fMRI task was completed by 12 motor CD patients and 14 matched healthy controls using standardised stimuli of faces with fearful and sad emotional expressions in comparison to faces with neutral expressions. Temporal changes in the sensitivity to stimuli were also modelled and tested in the two groups.

Results: We found increased amygdala activation to negative emotions in CD compared to healthy controls in region of interest analyses, which persisted over time consistent with previous findings using emotional paradigms. Furthermore during whole brain analyses we found significantly increased activation in CD patients in areas involved in the 'freeze response' to fear (periaqueductal grey matter), and areas involved in self-awareness and motor control (cingulate gyrus and supplementary motor area).

Conclusions: In contrast to healthy controls, CD patients exhibited increased response amplitude to fearful stimuli over time, suggesting abnormal emotional regulation (failure of habituation / sensitization). Patients with CD also activated midbrain and frontal structures that could reflect an abnormal behavioral-motor response to negative including threatening stimuli. This suggests a mechanism linking emotions to motor dysfunction in CD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Brain Mapping
  • Case-Control Studies
  • Conversion Disorder / diagnosis
  • Conversion Disorder / physiopathology*
  • Conversion Disorder / psychology*
  • Emotions*
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Models, Statistical
  • Motion*
  • Psychomotor Performance*
  • Young Adult