[HPV-induced anal lesions]

Hautarzt. 2015 Jun;66(6):439-45. doi: 10.1007/s00105-015-3630-0.
[Article in German]


Human papillomavirus (HPV) infections belong to the most common sexually transmitted infections. To date, more than 200 completely classified HPV-types have been reported, and those belonging to the genus alpha predominantly infect the anogenital region. Condylomata acuminata are caused by the two low-risk types HPV6 and HPV11 in more than 90 % of cases. Treatment of genital warts might be either ablative (e.g. electrocautery, surgical excision, or laser therapy) or topical (e.g. podophyllotoxine, trichloroacetic acid, or imiquimod), and depends on the size, location, morphology and anatomical region. Recurrences after treatment are frequent. Therefore, combination therapies (e.g. topical and ablative) play an important role in daily routine. HIV-infected individuals, especially HIV-positive MSM, have a strongly increased risk for anal dysplasia and anal cancer. Condylomata acuminata and a large proportion of anal dysplasia and anal carcinoma are preventable by prophylactic HPV-vaccination.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Anus Diseases / diagnosis*
  • Anus Diseases / therapy
  • Anus Neoplasms / diagnosis*
  • Anus Neoplasms / therapy
  • Condylomata Acuminata / diagnosis
  • Condylomata Acuminata / therapy
  • Female
  • Human papillomavirus 11
  • Human papillomavirus 6
  • Humans
  • Male
  • Papillomavirus Infections / diagnosis*
  • Papillomavirus Infections / therapy
  • Proctoscopy
  • Sexually Transmitted Diseases / diagnosis*
  • Sexually Transmitted Diseases / therapy