Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 21 (6), 941-949

Global Burden of Invasive Nontyphoidal Salmonella Disease, 2010(1)

Review

Global Burden of Invasive Nontyphoidal Salmonella Disease, 2010(1)

Trong T Ao et al. Emerg Infect Dis.

Abstract

Nontyphoidal Salmonella is a major cause of bloodstream infections worldwide, and HIV-infected persons and malaria-infected children are at increased risk for the disease. We conducted a systematic literature review to obtain age group-specific, population-based invasive nontyphoidal Salmonella (iNTS) incidence data. Data were categorized by HIV and malaria prevalence and then extrapolated by using 2010 population data. The case-fatality ratio (CFR) was determined by expert opinion consensus. We estimated that 3.4 (range 2.1-6.5) million cases of iNTS disease occur annually (overall incidence 49 cases [range 30-94] per 100,000 population). Africa, where infants, young children, and young adults are most affected, has the highest incidence (227 cases [range 152-341] per 100,000 population) and number of cases (1.9 [range 1.3-2.9] million cases). An iNTS CFR of 20% yielded 681,316 (range 415,164-1,301,520) deaths annually. iNTS disease is a major cause of illness and death globally, particularly in Africa. Improved understanding of the epidemiology of iNTS is needed.

Keywords: Salmonella; bacteremia; bacteria; global burden; incidence; invasive disease; nontyphoidal Salmonella disease.

Figures

Figure 1
Figure 1
Proportion of invasive nontyphoidal Salmonella disease, by age group, from low-incidence settings in the United States and high-incidence settings in Malawi and South Africa 2010.
Figure 2
Figure 2
Incidence of invasive nontyphoidal Salmonella disease, by age group, in countries with data identified through a global systematic review of the literature 2010.
Figure 3
Figure 3
HIV and malaria burden matrix and extrapolation strategy used to create reference age-specific incidence curves for invasive nontyphoidal Salmonella disease. *2010 Joint United Nations Program on HIV/AIDS (UNAIDS) HIV seroprevalence (15); †Malaria Atlas Project population at risk (PAR) estimate, defined as the proportion of the population living in an area of known Plasmodium falciparum transmission (16, 17); ‡US FoodNet (13).
Figure 4
Figure 4
Age-specific invasive nontyphoidal Salmonella disease incidence (cases/100,000 population) for various HIV and malaria settings, 2010. Number of lower right corner of each chart represents the number of countries in the category. Incidence is cases/100,000 population. Solid lines on each graph represent the estimated age-specific invasive nonthyphoidal Salmonella (iNTS) disease incidence; dotted lines represent ranges. A country is classified into 1 of the 8 categories on the basis of national HIV seroprevalence and malaria population at risk. The age-specific iNTS incidence in that category (solid line in graph) is then applied to the country’s population data to determine the number of cases and overall incidence of iNTS for the country. *2010 Joint United Nations Program on HIV/AIDS HIV seroprevalence (15); †Malaria Atlas Project population at risk estimate, defined as the proportion of the population living in an area of known Plasmodium falciparum transmission (16,17).
Figure 5
Figure 5
Results of a systematic review of the literature for the global burden of invasive nontyphoidal Salmonella disease. Reports published during January 1990–December 2012 were searched.

Similar articles

See all similar articles

Cited by 140 articles

See all "Cited by" articles

References

    1. Majowicz SE, Musto J, Scallan E, Angulo FJ, O'Brein SJ, Jones TF, et al. The global burden of nontyphoidal Salmonella gastroenteritis. Clin Infect Dis. 2010;50:882–9 . 10.1086/650733 - DOI - PubMed
    1. Murray CJ, Rosenfeld LC, Lim SS, Andrews KG, Foreman KJ, Haring D, et al. Global malaria mortality between 1980 and 2010: a systematic analysis. Lancet. 2012;379:413–31 . 10.1016/S0140-6736(12)60034-8 - DOI - PubMed
    1. Murray CJ, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380:2197–223 . 10.1016/S0140-6736(12)61689-4 - DOI - PubMed
    1. Reddy EA, Shaw AV, Crump JA. Community acquired bloodstream infections in Africa: a systematic review and meta-analysis. Lancet Infect Dis. 2010;10:417–32 . 10.1016/S1473-3099(10)70072-4 - DOI - PMC - PubMed
    1. Deen J, von Seidlein L, Andersen F, Elle N, White NJ, Lubell Y. Community-acquired bacterial bloodstream infections in developing countries in south and southeast Asia: a systematic review. Lancet Infect Dis. 2012;12:480–7 . 10.1016/S1473-3099(12)70028-2 - DOI - PubMed

MeSH terms

Feedback