A symmetric multivariate leakage correction for MEG connectomes

Neuroimage. 2015 Aug 15;117:439-48. doi: 10.1016/j.neuroimage.2015.03.071. Epub 2015 Apr 7.


Ambiguities in the source reconstruction of magnetoencephalographic (MEG) measurements can cause spurious correlations between estimated source time-courses. In this paper, we propose a symmetric orthogonalisation method to correct for these artificial correlations between a set of multiple regions of interest (ROIs). This process enables the straightforward application of network modelling methods, including partial correlation or multivariate autoregressive modelling, to infer connectomes, or functional networks, from the corrected ROIs. Here, we apply the correction to simulated MEG recordings of simple networks and to a resting-state dataset collected from eight subjects, before computing the partial correlations between power envelopes of the corrected ROItime-courses. We show accurate reconstruction of our simulated networks, and in the analysis of real MEGresting-state connectivity, we find dense bilateral connections within the motor and visual networks, together with longer-range direct fronto-parietal connections.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Computer Simulation
  • Connectome / methods*
  • Data Interpretation, Statistical*
  • Humans
  • Magnetoencephalography / methods*
  • Nerve Net / physiology*
  • Signal Processing, Computer-Assisted*