Depressed monocyte production of interleukin-1 and tumor necrosis factor-alpha in patients with alcoholic liver cirrhosis

Liver. 1989 Oct;9(5):302-6. doi: 10.1111/j.1600-0676.1989.tb00415.x.


Interleukin-1 and tumor necrosis factor-alpha activity by E. coli lipopolysaccharide-triggered monocytes were studied in patients with chronic alcoholic liver disease. Monocytes from cirrhotic patients were shown to have a significant reduction in IL-1 and TNF-a activity, compared with that from age- and sex-matched healthy controls. These findings indicate further immunoregulatory disturbances concerning alcoholic liver cirrhosis.

MeSH terms

  • Adult
  • Cytotoxicity Tests, Immunologic
  • Female
  • Humans
  • Interleukin-1 / metabolism*
  • Lipopolysaccharides / immunology
  • Liver Cirrhosis, Alcoholic / immunology*
  • Liver Function Tests
  • Male
  • Middle Aged
  • Monocytes / metabolism*
  • Tumor Cells, Cultured
  • Tumor Necrosis Factor-alpha / metabolism*


  • Interleukin-1
  • Lipopolysaccharides
  • Tumor Necrosis Factor-alpha