Clinical significance of CD155 expression in human pancreatic cancer

Anticancer Res. 2015 Apr;35(4):2287-97.


Background/aim: CD155 is expressed in many types of human cells and has diverse functions. We herein evaluated the clinical importance of CD155 in pancreatic cancer.

Materials and methods: We investigated CD155 expression in 134 patients with pancreatic cancer, and evaluated the correlations of CD155 with prognosis, tumor immunity and angiogenesis. Furthermore, CD155 functions were examined.

Results: CD155 expression was abundant in pancreatic cancer tissues. Patients with high CD155 expression had poorer postoperative prognosis than those with low expression. Multivariate analysis indicated that CD155 expression had a significant independent prognostic value. Tumor CD155 expression inversely correlated with the presence of tumor-infiltrating lymphocytes. Furthermore, it significantly positively correlated with vascular endothelial growth factor expression and intra tumoral microvessel density. In addition, silencing of CD155 inhibited proliferation, and induced cell-cycle arrest at G2/M phase in pancreatic cancer cells.

Conclusion: CD155 may play a critical role through both immunological and non-immuno logical mechanisms in pancreatic cancer and may be a therapeutic target for this intractable malignancy.

Keywords: CD155; angiogenesis; pancreatic cancer; prognostic factor; tumor immunity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Biomarkers, Tumor / biosynthesis*
  • Biomarkers, Tumor / immunology
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Neovascularization, Pathologic / genetics*
  • Neovascularization, Pathologic / pathology
  • Pancreatic Neoplasms / genetics*
  • Pancreatic Neoplasms / immunology
  • Pancreatic Neoplasms / pathology
  • Prognosis
  • Receptors, Virus / biosynthesis*
  • Receptors, Virus / genetics
  • Receptors, Virus / immunology
  • Vascular Endothelial Growth Factor A / genetics


  • Biomarkers, Tumor
  • Receptors, Virus
  • Vascular Endothelial Growth Factor A
  • poliovirus receptor