The molecular basis for the substrate specificity of protein tyrosine phosphatase PTPN3

Emily J Parker

doi:10.1016/j.str.2015.03.005

The molecular basis for the substrate specificity of protein tyrosine phosphatase PTPN3

Structure. 2015 Apr 7;23(4):608-9. doi: 10.1016/j.str.2015.03.005.

Author

Emily J Parker¹

Affiliation

¹ Maurice Wilkins Centre, Biomolecular Interaction Centre and Department of Chemistry, University of Canterbury, PO Box 4800, Christchurch 8140, New Zealand. Electronic address: emily.parker@canterbury.ac.nz.

PMID: 25862931
DOI: 10.1016/j.str.2015.03.005

Abstract

In this issue of Structure, Chen et al. present structures of the FERM-containing protein tyrosine phosphatase PTPN3 in complex with a phosphopeptide fragment of substrate epidermal growth factor receptor pathway substrate, providing detailed information on substrate specificity.

Publication types

Comment

MeSH terms

Adaptor Proteins, Signal Transducing / chemistry*
Humans
Molecular Docking Simulation*
Protein Tyrosine Phosphatase, Non-Receptor Type 3 / chemistry*

Substances

Adaptor Proteins, Signal Transducing
Protein Tyrosine Phosphatase, Non-Receptor Type 3