The molecular basis for the substrate specificity of protein tyrosine phosphatase PTPN3

Structure. 2015 Apr 7;23(4):608-9. doi: 10.1016/j.str.2015.03.005.


In this issue of Structure, Chen et al. present structures of the FERM-containing protein tyrosine phosphatase PTPN3 in complex with a phosphopeptide fragment of substrate epidermal growth factor receptor pathway substrate, providing detailed information on substrate specificity.

Publication types

  • Comment

MeSH terms

  • Adaptor Proteins, Signal Transducing / chemistry*
  • Humans
  • Molecular Docking Simulation*
  • Protein Tyrosine Phosphatase, Non-Receptor Type 3 / chemistry*


  • Adaptor Proteins, Signal Transducing
  • Protein Tyrosine Phosphatase, Non-Receptor Type 3