Tumor expression of adiponectin receptor 2 and lethal prostate cancer

Carcinogenesis. 2015 Jun;36(6):639-47. doi: 10.1093/carcin/bgv048. Epub 2015 Apr 11.


To investigate the role of adiponectin receptor 2 (AdipoR2) in aggressive prostate cancer we used immunohistochemistry to characterize AdipoR2 protein expression in tumor tissue for 866 men with prostate cancer from the Physicians' Health Study and the Health Professionals Follow-up Study. AdipoR2 tumor expression was not associated with measures of obesity, pathological tumor stage or prostate-specific antigen (PSA) at diagnosis. However, AdipoR2 expression was positively associated with proliferation as measured by Ki-67 expression quartiles (P-trend < 0.0001), with expression of fatty acid synthase (P-trend = 0.001), and with two measures of angiogenesis (P-trend < 0.1). An inverse association was observed with apoptosis as assessed by the TUNEL assay (P-trend = 0.006). Using Cox proportional hazards regression and controlling for age at diagnosis, Gleason score, year of diagnosis category, cohort and baseline BMI, we identified a statistically significant trend for the association between quartile of AdipoR2 expression and lethal prostate cancer (P-trend = 0.02). The hazard ratio for lethal prostate cancer for the two highest quartiles, as compared to the two lowest quartiles, of AdipoR2 expression was 1.9 (95% confidence interval [CI]: 1.2-3.0). Results were similar when additionally controlling for categories of PSA at diagnosis and Ki-67 expression quartiles. These results strengthen the evidence for the role of AdipoR2 in prostate cancer progression.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adiponectin / blood
  • Adult
  • Aged
  • Aged, 80 and over
  • Apoptosis
  • Biomarkers, Tumor
  • Cell Proliferation
  • Disease Progression
  • Fatty Acid Synthase, Type I / biosynthesis*
  • Humans
  • Ki-67 Antigen / biosynthesis
  • Male
  • Middle Aged
  • Neovascularization, Pathologic
  • Obesity / complications
  • Prospective Studies
  • Prostate-Specific Antigen / blood
  • Prostatic Neoplasms / mortality*
  • Prostatic Neoplasms / pathology*
  • Receptors, Adiponectin / biosynthesis*


  • ADIPOR2 protein, human
  • Adiponectin
  • Biomarkers, Tumor
  • Ki-67 Antigen
  • Receptors, Adiponectin
  • FASN protein, human
  • Fatty Acid Synthase, Type I
  • Prostate-Specific Antigen