Apple or pear: size and shape matter

Cell Metab. 2015 Apr 7;21(4):507-8. doi: 10.1016/j.cmet.2015.03.016.


Obesity-related morbidity and mortality are related to fat accumulation and fat distribution in humans. Two large-scale meta-analyses recently published in Nature by Shungin et al. (2015) and Locke et al. (2015) report novel genetic associations for central and overall obesity; these greatly advance our understanding of the biology of obesity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Adipose Tissue / metabolism*
  • Body Fat Distribution*
  • Body Mass Index*
  • Female
  • Genome-Wide Association Study*
  • Humans
  • Insulin / metabolism*
  • Male
  • Obesity / genetics*
  • Obesity / metabolism*
  • Quantitative Trait Loci / genetics*


  • Insulin